Nichole Owen

PhD
Assistant Clinical Director, Cytogenetics

Dr. Nichole Owen is currently an Assistant Clinical Director of Cytogenetics at Baylor Genetics. In addition to her role at BG, Dr. Owen is an Assistant Professor at Baylor College of Medicine and participates in fellow training.

Dr. Owen graduated with dual bachelor’s degrees in genetic & cell biology and microbiology from Washington State University in Pullman, WA. During this time, she began studying chromosomes, particularly meiotic recombination, and nondisjunction. She attended graduate school at Oregon Health and Science University (OHSU), where she studied genome instability disorders and chromosome instability and graduated with her PhD in molecular and medical genetics. Upon graduation, she continued with a postdoctoral fellowship at OHSU where she studied how acquired DNA repair defects underly the good responder phenotype in certain subtypes of acute myeloid leukemia.

Dr. Owen joined Baylor Genetics and Baylor College of Medicine (BCM) as a fellow in the Laboratory Genetics and Genomics Fellowship program in 2018. She is currently board eligible and will take the American Board of Medical Genetics and Genomics exam this year.

Position

Instructor
Baylor College of Medicine
Houston, TX, United States

Assistant Clinical Director
Baylor Genetics
Houston, TX, United States

Education

Postdoctoral Fellowship at Oregon Health & Science University
Portland, Oregon

PhD from Oregon Health & Science University
Portland, Oregon

BA from Washington State University
Pullman, Washington

Publications
Altered Cohesin Gene Dosage Affects Mammalian Meiotic Chromosome Structure and Behavior

Murdoch B*, Owen N*, Stevense M, Smith H, Nagaoka S, Hassold T, McKay M, Xu H, Fu J, Revenkova E, Jessberger R, and Hunt P (2013). Altered cohesin gene dosage affects mammalian meiotic chromosome structure and behavior. PLoS Genet. 9(2):e1003241. PMID: 23408896

Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM

Owen N, Hejna J, Rennie S, Mitchell A, Hanlon Newell A, Mitchell A, Moses RE and Olson SB (2014) Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM. Cytogenet Genome Res. 144(4): 255-263. PMID: 25766002

BLM protein mitigates formaldehyde-induced genomic instability

Kumari A, Owen N, Juarez E, McCullough AK (2015) BLM protein mitigates formaldehyde-induced genomic instability. DNA Repair (Amst) 28: 73-82. PMID: 25770783

Enhanced sensitivity of Neil1-/- mice to chronic UVB exposure

Calkins MJ, Vartanian V, Owen N, Kirkali G, Jaruga P, Dizdaroglu M, McCullough AK, Lloyd RS (2016) Enhanced sensitivity of Neil1-/- mice to chronic UVB exposure. DNA Repair (Amst.) 48:43-50. PMID: PMID: 27818081

FANCD2 facilitates replication through common fragile sites

Madireddy A, Kosiyatrakul ST, Gerhardt J, Boisvert RA, Vuono EA, Moyano EH, Rubio MLG, Owen N, Yan Z, Olson S, Aguilera A, Howlett NG, Schildkraut CL. (2016) FANCD2 facilitates replication through common fragile sites Mol Cell 64(2):388-404. PMID: 27768874

Modulation of UVB-induced carcinogenesis by activation of alternative DNA repair pathways

Sha Y, Vartanian V, Owen N, Koon S, Calkins M, Mir S, Goldsmith L, He H, Luo C, Brown S, Doetsch P, Kaempf A, Lim J, McCullough A, Lloyd RS.  (2018) Modulation of UVB-induced carcinogenesis by activation of alternative DNA repair pathways. Sci Rep 8(1):705

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

Allison J Schaser, Valerie R Osterberg, Sydney E Dent, Teresa L Stackhouse, Colin M Wakeham, Sydney W Boutros, Leah J Weston, Nichole Owen, Tamily A Weissman, Esteban Luna, Jacob Raber, Kelvin C Luk, Amanda K McCullough, Randall L Woltjer, Vivek K Unni (2019) “Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders”. Sci Rep. 9(1):10919. PMID: 31358782

Nichole Owen

PhD
Assistant Clinical Director, Cytogenetics

Dr. Nichole Owen is currently an Assistant Clinical Director of Cytogenetics at Baylor Genetics. In addition to her role at BG, Dr. Owen is an Assistant Professor at Baylor College of Medicine and participates in fellow training.

Dr. Owen graduated with dual bachelor’s degrees in genetic & cell biology and microbiology from Washington State University in Pullman, WA. During this time, she began studying chromosomes, particularly meiotic recombination, and nondisjunction. She attended graduate school at Oregon Health and Science University (OHSU), where she studied genome instability disorders and chromosome instability and graduated with her PhD in molecular and medical genetics. Upon graduation, she continued with a postdoctoral fellowship at OHSU where she studied how acquired DNA repair defects underly the good responder phenotype in certain subtypes of acute myeloid leukemia.

Dr. Owen joined Baylor Genetics and Baylor College of Medicine (BCM) as a fellow in the Laboratory Genetics and Genomics Fellowship program in 2018. She is currently board eligible and will take the American Board of Medical Genetics and Genomics exam this year.

Position

Instructor
Baylor College of Medicine
Houston, TX, United States

Assistant Clinical Director
Baylor Genetics
Houston, TX, United States

Education

Postdoctoral Fellowship at Oregon Health & Science University
Portland, Oregon

PhD from Oregon Health & Science University
Portland, Oregon

BA from Washington State University
Pullman, Washington

Publications
Altered Cohesin Gene Dosage Affects Mammalian Meiotic Chromosome Structure and Behavior

Murdoch B*, Owen N*, Stevense M, Smith H, Nagaoka S, Hassold T, McKay M, Xu H, Fu J, Revenkova E, Jessberger R, and Hunt P (2013). Altered cohesin gene dosage affects mammalian meiotic chromosome structure and behavior. PLoS Genet. 9(2):e1003241. PMID: 23408896

Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM

Owen N, Hejna J, Rennie S, Mitchell A, Hanlon Newell A, Mitchell A, Moses RE and Olson SB (2014) Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM. Cytogenet Genome Res. 144(4): 255-263. PMID: 25766002

BLM protein mitigates formaldehyde-induced genomic instability

Kumari A, Owen N, Juarez E, McCullough AK (2015) BLM protein mitigates formaldehyde-induced genomic instability. DNA Repair (Amst) 28: 73-82. PMID: 25770783

Enhanced sensitivity of Neil1-/- mice to chronic UVB exposure

Calkins MJ, Vartanian V, Owen N, Kirkali G, Jaruga P, Dizdaroglu M, McCullough AK, Lloyd RS (2016) Enhanced sensitivity of Neil1-/- mice to chronic UVB exposure. DNA Repair (Amst.) 48:43-50. PMID: PMID: 27818081

FANCD2 facilitates replication through common fragile sites

Madireddy A, Kosiyatrakul ST, Gerhardt J, Boisvert RA, Vuono EA, Moyano EH, Rubio MLG, Owen N, Yan Z, Olson S, Aguilera A, Howlett NG, Schildkraut CL. (2016) FANCD2 facilitates replication through common fragile sites Mol Cell 64(2):388-404. PMID: 27768874

Modulation of UVB-induced carcinogenesis by activation of alternative DNA repair pathways

Sha Y, Vartanian V, Owen N, Koon S, Calkins M, Mir S, Goldsmith L, He H, Luo C, Brown S, Doetsch P, Kaempf A, Lim J, McCullough A, Lloyd RS.  (2018) Modulation of UVB-induced carcinogenesis by activation of alternative DNA repair pathways. Sci Rep 8(1):705

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

Allison J Schaser, Valerie R Osterberg, Sydney E Dent, Teresa L Stackhouse, Colin M Wakeham, Sydney W Boutros, Leah J Weston, Nichole Owen, Tamily A Weissman, Esteban Luna, Jacob Raber, Kelvin C Luk, Amanda K McCullough, Randall L Woltjer, Vivek K Unni (2019) “Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders”. Sci Rep. 9(1):10919. PMID: 31358782

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