Nichole Owen
PhD
Associate Clinical Director, Next Generation Cytogenetics
Dr. Nichole Owen is currently an Associate Clinical Director of Next Generation Cytogenetics at Baylor Genetics. In addition to her role at BG, Dr. Owen is an Assistant Professor at Baylor College of Medicine and participates in fellow training.
Dr. Owen graduated with dual bachelor’s degrees in genetic & cell biology and microbiology from Washington State University in Pullman, WA. During this time, she began studying chromosomes, particularly meiotic recombination, and nondisjunction. She attended graduate school at Oregon Health and Science University (OHSU), where she studied genome instability disorders and chromosome instability and graduated with her PhD in molecular and medical genetics. Upon graduation, she continued with a postdoctoral fellowship at OHSU where she studied how acquired DNA repair defects underly the good responder phenotype in certain subtypes of acute myeloid leukemia.
Dr. Owen joined Baylor Genetics and Baylor College of Medicine (BCM) as a fellow in the Laboratory Genetics and Genomics Fellowship program in 2018. She is currently board eligible and will take the American Board of Medical Genetics and Genomics exam this year.
Position
Instructor
Baylor College of Medicine
Houston, TX, United States
Assistant Clinical Director
Baylor Genetics
Houston, TX, United States
Education
Postdoctoral Fellowship at Oregon Health & Science University
Portland, Oregon
PhD from Oregon Health & Science University
Portland, Oregon
BA from Washington State University
Pullman, Washington
Publications
Altered Cohesin Gene Dosage Affects Mammalian Meiotic Chromosome Structure and Behavior
Murdoch B*, Owen N*, Stevense M, Smith H, Nagaoka S, Hassold T, McKay M, Xu H, Fu J, Revenkova E, Jessberger R, and Hunt P (2013). Altered cohesin gene dosage affects mammalian meiotic chromosome structure and behavior. PLoS Genet. 9(2):e1003241. PMID: 23408896
Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM
Owen N, Hejna J, Rennie S, Mitchell A, Hanlon Newell A, Mitchell A, Moses RE and Olson SB (2014) Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM. Cytogenet Genome Res. 144(4): 255-263. PMID: 25766002
BLM protein mitigates formaldehyde-induced genomic instability
Kumari A, Owen N, Juarez E, McCullough AK (2015) BLM protein mitigates formaldehyde-induced genomic instability. DNA Repair (Amst) 28: 73-82. PMID: 25770783
Enhanced sensitivity of Neil1-/- mice to chronic UVB exposure
Calkins MJ, Vartanian V, Owen N, Kirkali G, Jaruga P, Dizdaroglu M, McCullough AK, Lloyd RS (2016) Enhanced sensitivity of Neil1-/- mice to chronic UVB exposure. DNA Repair (Amst.) 48:43-50. PMID: PMID: 27818081
FANCD2 facilitates replication through common fragile sites
Madireddy A, Kosiyatrakul ST, Gerhardt J, Boisvert RA, Vuono EA, Moyano EH, Rubio MLG, Owen N, Yan Z, Olson S, Aguilera A, Howlett NG, Schildkraut CL. (2016) FANCD2 facilitates replication through common fragile sites Mol Cell 64(2):388-404. PMID: 27768874
DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure
Lin YC, Owen N, Lange S, Li L, Stone M, Wood R, McCullough A, Lloyd RS. (2016) DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure. Proc Natl Acad Sci USA. 113(48):13774-13779. PMID: 31410467
A new rhesus macaque karyotype based on human-rhesus synteny
Owen N, Lawce, HJ, Olson SB (2016) A new rhesus macaque karyotype based on human-rhesus synteny. J Assoc Genet Technol. 42(4):178-179. PMID: 27849185
Modulation of UVB-induced carcinogenesis by activation of alternative DNA repair pathways
Sha Y, Vartanian V, Owen N, Koon S, Calkins M, Mir S, Goldsmith L, He H, Luo C, Brown S, Doetsch P, Kaempf A, Lim J, McCullough A, Lloyd RS. (2018) Modulation of UVB-induced carcinogenesis by activation of alternative DNA repair pathways. Sci Rep 8(1):705
An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity
Juarez E, Chambwe N, Tang W, Mitchell AD, Owen N, Kumari A, Monnat RJ Jr, McCullough AK. (2018) An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity. DNA Repair (Amst). 72:1-9. PMID: 30389308
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders
Allison J Schaser, Valerie R Osterberg, Sydney E Dent, Teresa L Stackhouse, Colin M Wakeham, Sydney W Boutros, Leah J Weston, Nichole Owen, Tamily A Weissman, Esteban Luna, Jacob Raber, Kelvin C Luk, Amanda K McCullough, Randall L Woltjer, Vivek K Unni (2019) “Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders”. Sci Rep. 9(1):10919. PMID: 31358782
Nichole Owen
PhD
Associate Clinical Director, Next Generation Cytogenetics
Dr. Nichole Owen is currently an Associate Clinical Director of Next Generation Cytogenetics at Baylor Genetics. In addition to her role at BG, Dr. Owen is an Assistant Professor at Baylor College of Medicine and participates in fellow training.
Dr. Owen graduated with dual bachelor’s degrees in genetic & cell biology and microbiology from Washington State University in Pullman, WA. During this time, she began studying chromosomes, particularly meiotic recombination, and nondisjunction. She attended graduate school at Oregon Health and Science University (OHSU), where she studied genome instability disorders and chromosome instability and graduated with her PhD in molecular and medical genetics. Upon graduation, she continued with a postdoctoral fellowship at OHSU where she studied how acquired DNA repair defects underly the good responder phenotype in certain subtypes of acute myeloid leukemia.
Dr. Owen joined Baylor Genetics and Baylor College of Medicine (BCM) as a fellow in the Laboratory Genetics and Genomics Fellowship program in 2018. She is currently board eligible and will take the American Board of Medical Genetics and Genomics exam this year.
Position
Instructor
Baylor College of Medicine
Houston, TX, United States
Assistant Clinical Director
Baylor Genetics
Houston, TX, United States
Education
Postdoctoral Fellowship at Oregon Health & Science University
Portland, Oregon
PhD from Oregon Health & Science University
Portland, Oregon
BA from Washington State University
Pullman, Washington
Publications
Altered Cohesin Gene Dosage Affects Mammalian Meiotic Chromosome Structure and Behavior
Murdoch B*, Owen N*, Stevense M, Smith H, Nagaoka S, Hassold T, McKay M, Xu H, Fu J, Revenkova E, Jessberger R, and Hunt P (2013). Altered cohesin gene dosage affects mammalian meiotic chromosome structure and behavior. PLoS Genet. 9(2):e1003241. PMID: 23408896
Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM
Owen N, Hejna J, Rennie S, Mitchell A, Hanlon Newell A, Mitchell A, Moses RE and Olson SB (2014) Bloom syndrome radials are predominantly non-homologous and are suppressed by phosphorylated BLM. Cytogenet Genome Res. 144(4): 255-263. PMID: 25766002
BLM protein mitigates formaldehyde-induced genomic instability
Kumari A, Owen N, Juarez E, McCullough AK (2015) BLM protein mitigates formaldehyde-induced genomic instability. DNA Repair (Amst) 28: 73-82. PMID: 25770783
Enhanced sensitivity of Neil1-/- mice to chronic UVB exposure
Calkins MJ, Vartanian V, Owen N, Kirkali G, Jaruga P, Dizdaroglu M, McCullough AK, Lloyd RS (2016) Enhanced sensitivity of Neil1-/- mice to chronic UVB exposure. DNA Repair (Amst.) 48:43-50. PMID: PMID: 27818081
FANCD2 facilitates replication through common fragile sites
Madireddy A, Kosiyatrakul ST, Gerhardt J, Boisvert RA, Vuono EA, Moyano EH, Rubio MLG, Owen N, Yan Z, Olson S, Aguilera A, Howlett NG, Schildkraut CL. (2016) FANCD2 facilitates replication through common fragile sites Mol Cell 64(2):388-404. PMID: 27768874
DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure
Lin YC, Owen N, Lange S, Li L, Stone M, Wood R, McCullough A, Lloyd RS. (2016) DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure. Proc Natl Acad Sci USA. 113(48):13774-13779. PMID: 31410467
A new rhesus macaque karyotype based on human-rhesus synteny
Owen N, Lawce, HJ, Olson SB (2016) A new rhesus macaque karyotype based on human-rhesus synteny. J Assoc Genet Technol. 42(4):178-179. PMID: 27849185
Modulation of UVB-induced carcinogenesis by activation of alternative DNA repair pathways
Sha Y, Vartanian V, Owen N, Koon S, Calkins M, Mir S, Goldsmith L, He H, Luo C, Brown S, Doetsch P, Kaempf A, Lim J, McCullough A, Lloyd RS. (2018) Modulation of UVB-induced carcinogenesis by activation of alternative DNA repair pathways. Sci Rep 8(1):705
An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity
Juarez E, Chambwe N, Tang W, Mitchell AD, Owen N, Kumari A, Monnat RJ Jr, McCullough AK. (2018) An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity. DNA Repair (Amst). 72:1-9. PMID: 30389308
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders
Allison J Schaser, Valerie R Osterberg, Sydney E Dent, Teresa L Stackhouse, Colin M Wakeham, Sydney W Boutros, Leah J Weston, Nichole Owen, Tamily A Weissman, Esteban Luna, Jacob Raber, Kelvin C Luk, Amanda K McCullough, Randall L Woltjer, Vivek K Unni (2019) “Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders”. Sci Rep. 9(1):10919. PMID: 31358782