

Linyan Meng
PhD
Dr. Linyan Meng serves as the Division Director of Next-Generation Sequencing, Molecular Diagnostics, and CGI at Baylor Genetics. In her current role, her primary specialties are universal carrier screening, whole-exome sequencing, and targeted genotyping analysis. In addition to her role at BG, Dr. Meng is the Assistant Professor in the Department of Molecular and Human Genetics at Baylor College of Medicine (BCM).
Dr. Meng earned her PhD in Molecular and Human Genetics from BCM in Houston, TX. Following her PhD, Dr. Meng completed her two-year ABMGG fellowship in Clinical Molecular Genetics at BCM.
Dr. Meng’s research has been published in several prestigious international journals, including Nature, JAMA Pediatrics, American Journal of Human Genetics, PloS Genetics, and Human Molecular Genetics.
Assistant Professor
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, United States
Sr. Division Director
NGS/Molecular/CGI
Baylor Genetics
Houston, TX, United States
PhD from Baylor College of Medicine
Houston, Texas, United States
BS from Peking University
Beijing, China
A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencingx
Copy number variant and runs of homozygosity detection by microarrays enabled more precise molecular diagnoses in 11,020 clinical exome cases
Interchromosomal template-switching as a novel molecular mechanism for imprinting perturbations associated with Temple syndrome
Reanalysis of Clinical Exome Sequencing Data
Liu, P., Meng, L., Normand, E.A., Xia, F., Song, X., Ghazi, A., Rosenfeld, J., Magoulas, P.L., Braxton, A., Ward, P., Dai, H., Yuan, B., Bi, W., Xiao, R., Wang, X., Chiang, T., Vetrini, F., He, W., Cheng, H., Dong, J., Gijavanekar, C., Benke, P.J., Bernstein, J.A., Eble, T., Eroglu, Y., Erwin, D., Escobar, L., Gibson, J.B., Gripp, K., Kleppe, S., Koenig, M.K., Lewis, A.M., Natowicz, M., Mancias, P., Minor, L., Scaglia, F., Schaaf, C.P., Streff, H., Vernon, H., Uhles, C.L., Zackai, E.H., Wu, N., Sutton, V.R., Beaudet, A.L., Muzny, D., Gibbs, R.A., Posey, J.E., Lalani, S., Shaw, C., Eng, C.M., Lupski, J.R., and Yang, Y. (2019). Reanalysis of Clinical Exome Sequencing Data. N Engl J Med 380, 2478-2480. PMID: 31216405
Clinical validity of expanded carrier screening: Evaluating the gene-disease relationship in more than 200 conditions
Clinical validity of expanded carrier screening: Evaluating the gene-disease relationship in more than 200 conditions. Marie Balzotti, Linyan Meng, Dale Muzzey, Katherine Johansen Taber, Kyle Beauchamp, Myriad Genetics Curation Team, Baylor Genetics Curation Team, Rebecca Mar-Heyming, Bethany Buckley, Krista Moyer. Hum Mutat. 2020 Aug; 41(8): 1365–1371. PMID: 32383249
A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing
Ye Cao, Mari J. Tokita, Edward S. Chen, Rajarshi Ghosh, Tiansheng Chen, Yanming Feng, Elizabeth Gorman, Federica Gibellini, Patricia A. Ward, Alicia Braxton, Xia Wang, Linyan Meng, Rui Xiao, Weimin Bi, Fan Xia, Christine M. Eng, Yaping Yang, Tomasz Gambin, Chad Shaw, Pengfei Liu & Pawel Stankiewicz (2019). A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing. Genome Med 11, 12. PMID: 31349857
A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay
Schoch K, Meng L, Szelinger S, Bearden DR, Stray-Pedersen A, Busk OL, Stong N, Liston E, Cohn RD, Scaglia F, Rosenfeld JA, Tarpinian J, Skraban CM, Deardorff MA, Friedman JN, Akdemir ZC, Walley N, Mikati MA, Kranz PG, Jasien J, McConkie-Rosell A, McDonald M, Wechsler SB, Freemark M, Kansagra S, Freedman S, Bali D, Millan F, Bale S, Nelson SF, Lee H, Dorrani N; UCLA Clinical Genomics Center.; Undiagnosed Diseases Network., Goldstein DB, Xiao R, Yang Y, Posey JE, Martinez-Agosto JA, Lupski JR, Wangler MF, Shashi V. A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay. Am J Hum Genet. 100(2):343-351, 2017. PMID: 28132692
Homozygous variants in pyrroline-5-carboxylate reductase 2 (PYCR2) in patients with progressive microcephaly and hypomyelinating leukodystrophy
Meng L, Donti T, Xia F, Niu Z, Al Shamsi A, Hertecant J, Al-Jasmi F, Gibson JB, Nagakura H, Zhang J, He W, Eng C, Yang Y, Elsea SH. Homozygous variants in pyrroline-5-carboxylate reductase 2 (PYCR2) in patients with progressive microcephaly and hypomyelinating leukodystrophy. Am J Med Genet A. 2017 Feb;173(2):460-470. PMID: 27860360

Linyan Meng
PhD
Dr. Linyan Meng serves as the Division Director of Next-Generation Sequencing, Molecular Diagnostics, and CGI at Baylor Genetics. In her current role, her primary specialties are universal carrier screening, whole-exome sequencing, and targeted genotyping analysis. In addition to her role at BG, Dr. Meng is the Assistant Professor in the Department of Molecular and Human Genetics at Baylor College of Medicine (BCM).
Dr. Meng earned her PhD in Molecular and Human Genetics from BCM in Houston, TX. Following her PhD, Dr. Meng completed her two-year ABMGG fellowship in Clinical Molecular Genetics at BCM.
Dr. Meng’s research has been published in several prestigious international journals, including Nature, JAMA Pediatrics, American Journal of Human Genetics, PloS Genetics, and Human Molecular Genetics.
Assistant Professor
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, United States
Sr. Division Director
NGS/Molecular/CGI
Baylor Genetics
Houston, TX, United States
PhD from Baylor College of Medicine
Houston, Texas, United States
BS from Peking University
Beijing, China
A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencingx
Copy number variant and runs of homozygosity detection by microarrays enabled more precise molecular diagnoses in 11,020 clinical exome cases
Interchromosomal template-switching as a novel molecular mechanism for imprinting perturbations associated with Temple syndrome
Reanalysis of Clinical Exome Sequencing Data
Liu, P., Meng, L., Normand, E.A., Xia, F., Song, X., Ghazi, A., Rosenfeld, J., Magoulas, P.L., Braxton, A., Ward, P., Dai, H., Yuan, B., Bi, W., Xiao, R., Wang, X., Chiang, T., Vetrini, F., He, W., Cheng, H., Dong, J., Gijavanekar, C., Benke, P.J., Bernstein, J.A., Eble, T., Eroglu, Y., Erwin, D., Escobar, L., Gibson, J.B., Gripp, K., Kleppe, S., Koenig, M.K., Lewis, A.M., Natowicz, M., Mancias, P., Minor, L., Scaglia, F., Schaaf, C.P., Streff, H., Vernon, H., Uhles, C.L., Zackai, E.H., Wu, N., Sutton, V.R., Beaudet, A.L., Muzny, D., Gibbs, R.A., Posey, J.E., Lalani, S., Shaw, C., Eng, C.M., Lupski, J.R., and Yang, Y. (2019). Reanalysis of Clinical Exome Sequencing Data. N Engl J Med 380, 2478-2480. PMID: 31216405
Clinical validity of expanded carrier screening: Evaluating the gene-disease relationship in more than 200 conditions
Clinical validity of expanded carrier screening: Evaluating the gene-disease relationship in more than 200 conditions. Marie Balzotti, Linyan Meng, Dale Muzzey, Katherine Johansen Taber, Kyle Beauchamp, Myriad Genetics Curation Team, Baylor Genetics Curation Team, Rebecca Mar-Heyming, Bethany Buckley, Krista Moyer. Hum Mutat. 2020 Aug; 41(8): 1365–1371. PMID: 32383249
A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing
Ye Cao, Mari J. Tokita, Edward S. Chen, Rajarshi Ghosh, Tiansheng Chen, Yanming Feng, Elizabeth Gorman, Federica Gibellini, Patricia A. Ward, Alicia Braxton, Xia Wang, Linyan Meng, Rui Xiao, Weimin Bi, Fan Xia, Christine M. Eng, Yaping Yang, Tomasz Gambin, Chad Shaw, Pengfei Liu & Pawel Stankiewicz (2019). A clinical survey of mosaic single nucleotide variants in disease-causing genes detected by exome sequencing. Genome Med 11, 12. PMID: 31349857
A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay
Schoch K, Meng L, Szelinger S, Bearden DR, Stray-Pedersen A, Busk OL, Stong N, Liston E, Cohn RD, Scaglia F, Rosenfeld JA, Tarpinian J, Skraban CM, Deardorff MA, Friedman JN, Akdemir ZC, Walley N, Mikati MA, Kranz PG, Jasien J, McConkie-Rosell A, McDonald M, Wechsler SB, Freemark M, Kansagra S, Freedman S, Bali D, Millan F, Bale S, Nelson SF, Lee H, Dorrani N; UCLA Clinical Genomics Center.; Undiagnosed Diseases Network., Goldstein DB, Xiao R, Yang Y, Posey JE, Martinez-Agosto JA, Lupski JR, Wangler MF, Shashi V. A Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay. Am J Hum Genet. 100(2):343-351, 2017. PMID: 28132692
Homozygous variants in pyrroline-5-carboxylate reductase 2 (PYCR2) in patients with progressive microcephaly and hypomyelinating leukodystrophy
Meng L, Donti T, Xia F, Niu Z, Al Shamsi A, Hertecant J, Al-Jasmi F, Gibson JB, Nagakura H, Zhang J, He W, Eng C, Yang Y, Elsea SH. Homozygous variants in pyrroline-5-carboxylate reductase 2 (PYCR2) in patients with progressive microcephaly and hypomyelinating leukodystrophy. Am J Med Genet A. 2017 Feb;173(2):460-470. PMID: 27860360