Hongzheng Dai

PhD
Associate Clinical Director, NGS/Molecular

Dr. Hongzheng Dai serves as the Associate Clinical Director of NGS/ Molecular at Baylor Genetics. In his current role, he explores possible diagnoses for genetic disorders through the analysis and review of genetics and genomics data from various research projects and clinical genetic services. In addition to his role at BG, Dr. Dai is an Assistant Professor at Baylor College of Medicine.  

Dr. Dai received his doctorate in genetics from the University of Chicago and completed his postdoctoral trainings at Rockefeller and Johns Hopkins University. Three years after joining the Medical Genetics Laboratories at BCM, he obtained his ABMGG clinical molecular genetics and genomics training at Baylor College of Medicine.  

Dr. Dai has abundant experience in basic research and clinical genetics. In addition, he has been involved in multiple research and development projects in the diagnostic lab, inter-institutional consortium teams, and peer-review publications.

Position

Assistant Professor
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, United States

Associate Clinical Director
NGS/Molecular
Baylor Genetics
Houston, TX, United States

Education

PhD from University of Chicago
Chicago, IL, United States

MA from Tsinghua University
Beijing, China

BA from Tsinghua University
Beijing, China

Certifications

MB
American Society for Clinical Pathology

Board Eligible in Clinical Molecular Genetics and Genomics
American Board of Medical Genetics and Genomics

Publications
Reanalysis of Clinical Exome Sequencing Data

Liu, P., Meng, L., Normand, E.A., Xia, F., Song, X., Ghazi, A., Rosenfeld, J., Magoulas, P.L., Braxton, A., Ward, P., Dai, H., Yuan, B., Bi, W., Xiao, R., Wang, X., Chiang, T., Vetrini, F., He, W., Cheng, H., Dong, J., Gijavanekar, C., Benke, P.J., Bernstein, J.A., Eble, T., Eroglu, Y., Erwin, D., Escobar, L., Gibson, J.B., Gripp, K., Kleppe, S., Koenig, M.K., Lewis, A.M., Natowicz, M., Mancias, P., Minor, L., Scaglia, F., Schaaf, C.P., Streff, H., Vernon, H., Uhles, C.L., Zackai, E.H., Wu, N., Sutton, V.R., Beaudet, A.L., Muzny, D., Gibbs, R.A., Posey, J.E., Lalani, S., Shaw, C., Eng, C.M., Lupski, J.R., and Yang, Y. (2019). Reanalysis of Clinical Exome Sequencing Data. N Engl J Med 380, 2478-2480. PMID: 31216405

A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 gene

Li J, Dai H, Feng Y, Tang J, Chen S, Tian X, Gorman E, Schmitt ES, Hansen T, Wang J, Plon SE, Zhang VW, Wong LJ.  A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 geneJ Mol Diagn. 2015 Sep;17(5):545-53.  doi: 10.1016/j.jmoldx. 2015.04.001. [with Press Release]  PMID: 26320870

Molecular and clinical spectra of FBXL4 deficiency

El-Hattab AW, Dai H, Almannai M, Wang J et al. (2017) Molecular and clinical spectra of FBXL4 Hum Mutat. 38:1649-1659. PMID: 28940506

FBXL4 defects are common in patients with congenital lactic acidemia and encephalomyopathic mitochondrial DNA depletion syndrome.

Dai H, Zhang W, El-hattab AW, Ficicioglu C, Shinawi M, Lines M, Schulze A, McNutt M, Gotway G, Tian X, Chen S, Wang J, Craigen WJ, Wong LJ. (2017) FBXL4 defects are common in patients with congenital lactic acidemia and encephalomyopathic mitochondrial DNA depletion syndrome. Clin Genet. 91:634-39. PMID: 27743463

MPV17-related mitochondrial DNA maintenance defect: new cases and review of clinical, biochemical, and molecular aspects

El-Hattab AW, Wang J, Dai H et al, (2018) MPV17-related mitochondrial DNA maintenance defect: new cases and review of clinical, biochemical, and molecular aspects. Hum Mutat (In press)

FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion Syndrome

Almannai M, Dai H, El-Hattab AW, Wong LJC. (2017) FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion Syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mefford HC, Stephens K, Amemiya A, Ledbetter N, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2017. PMID: 28383868

Hongzheng Dai

PhD
Associate Clinical Director, NGS/Molecular

Dr. Hongzheng Dai serves as the Associate Clinical Director of NGS/ Molecular at Baylor Genetics. In his current role, he explores possible diagnoses for genetic disorders through the analysis and review of genetics and genomics data from various research projects and clinical genetic services. In addition to his role at BG, Dr. Dai is an Assistant Professor at Baylor College of Medicine.  

Dr. Dai received his doctorate in genetics from the University of Chicago and completed his postdoctoral trainings at Rockefeller and Johns Hopkins University. Three years after joining the Medical Genetics Laboratories at BCM, he obtained his ABMGG clinical molecular genetics and genomics training at Baylor College of Medicine.  

Dr. Dai has abundant experience in basic research and clinical genetics. In addition, he has been involved in multiple research and development projects in the diagnostic lab, inter-institutional consortium teams, and peer-review publications.

Position

Assistant Professor
Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, United States

Associate Clinical Director
NGS/Molecular
Baylor Genetics
Houston, TX, United States

Education

PhD from University of Chicago
Chicago, IL, United States

MA from Tsinghua University
Beijing, China

BA from Tsinghua University
Beijing, China

Certifications

MB
American Society for Clinical Pathology

Board Eligible in Clinical Molecular Genetics and Genomics
American Board of Medical Genetics and Genomics

Publications
Reanalysis of Clinical Exome Sequencing Data

Liu, P., Meng, L., Normand, E.A., Xia, F., Song, X., Ghazi, A., Rosenfeld, J., Magoulas, P.L., Braxton, A., Ward, P., Dai, H., Yuan, B., Bi, W., Xiao, R., Wang, X., Chiang, T., Vetrini, F., He, W., Cheng, H., Dong, J., Gijavanekar, C., Benke, P.J., Bernstein, J.A., Eble, T., Eroglu, Y., Erwin, D., Escobar, L., Gibson, J.B., Gripp, K., Kleppe, S., Koenig, M.K., Lewis, A.M., Natowicz, M., Mancias, P., Minor, L., Scaglia, F., Schaaf, C.P., Streff, H., Vernon, H., Uhles, C.L., Zackai, E.H., Wu, N., Sutton, V.R., Beaudet, A.L., Muzny, D., Gibbs, R.A., Posey, J.E., Lalani, S., Shaw, C., Eng, C.M., Lupski, J.R., and Yang, Y. (2019). Reanalysis of Clinical Exome Sequencing Data. N Engl J Med 380, 2478-2480. PMID: 31216405

A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 gene

Li J, Dai H, Feng Y, Tang J, Chen S, Tian X, Gorman E, Schmitt ES, Hansen T, Wang J, Plon SE, Zhang VW, Wong LJ.  A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 geneJ Mol Diagn. 2015 Sep;17(5):545-53.  doi: 10.1016/j.jmoldx. 2015.04.001. [with Press Release]  PMID: 26320870

Molecular and clinical spectra of FBXL4 deficiency

El-Hattab AW, Dai H, Almannai M, Wang J et al. (2017) Molecular and clinical spectra of FBXL4 Hum Mutat. 38:1649-1659. PMID: 28940506

FBXL4 defects are common in patients with congenital lactic acidemia and encephalomyopathic mitochondrial DNA depletion syndrome.

Dai H, Zhang W, El-hattab AW, Ficicioglu C, Shinawi M, Lines M, Schulze A, McNutt M, Gotway G, Tian X, Chen S, Wang J, Craigen WJ, Wong LJ. (2017) FBXL4 defects are common in patients with congenital lactic acidemia and encephalomyopathic mitochondrial DNA depletion syndrome. Clin Genet. 91:634-39. PMID: 27743463

MPV17-related mitochondrial DNA maintenance defect: new cases and review of clinical, biochemical, and molecular aspects

El-Hattab AW, Wang J, Dai H et al, (2018) MPV17-related mitochondrial DNA maintenance defect: new cases and review of clinical, biochemical, and molecular aspects. Hum Mutat (In press)

FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion Syndrome

Almannai M, Dai H, El-Hattab AW, Wong LJC. (2017) FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion Syndrome. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mefford HC, Stephens K, Amemiya A, Ledbetter N, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2017. PMID: 28383868

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