Houston, August 18, 2025 — Baylor Genetics, a clinical diagnostic laboratory at the forefront of genetic testing, today announced their participation at the Annual Meeting of the Cancer Genomics Consortium, which took place August 3-6, 2025, in Houston, TX.
What:
Baylor Genetics presented a scientific poster titled “Continued Utility of Chromosome Analysis for Plasma Cell Disorders,” highlighting the diagnostic value of conventional chromosome analysis alongside plasma cell-enriched FISH testing. The study reinforces the importance of a comprehensive approach to cytogenetic testing, showing that chromosome analysis can reveal additional, clinically relevant anomalies often missed by FISH alone.
Who:
Dr. Janice Smith, Senior Clinical Director at Baylor Genetics and Assistant Professor at Baylor College of Medicine
Why It Matters:
While plasma cell-enriched FISH has become a mainstay in the evaluation of Plasma Cell Neoplasm (PCN) due to its high detection rate for common abnormalities, this study underscores that chromosome analysis still plays a vital complementary role. In a review of over 1,500 cases with PCN-related indications, chromosome analysis revealed:
Key Findings:
- Constitutional and acquired abnormalities not detected by FISH
- Complex clonal architecture in advanced disease stages
- Co-existing myeloid and lymphoid clones that could influence treatment and prognosis
- Structural variants, such as unbalanced translocations and chromosomal deletions, with potential diagnostic or prognostic relevance
The findings support a dual testing approach—FISH and chromosome analysis—for a more complete genetic picture, particularly in cases with atypical clinical features or evolving disease.
About Baylor Genetics
Baylor Genetics is a leading diagnostic genomics partner offering a full spectrum of clinically relevant genetic testing, including Whole Genome Sequencing, Whole Exome Sequencing, and focused panels. Baylor Genetics combines rapid and comprehensive precision diagnostics options with the support of genetic counselors to help clinicians avoid a lengthy diagnostic odyssey for their patients, guide medical management, and ensure no patient with a genetic disorder gets left behind. Baylor Genetics’ testing menu covers family planning, pregnancy, neonatal and pediatric testing, oncology, and many other specialized testing options. Located in Houston’s Texas Medical Center, Baylor Genetics serves clients in 50 states and 16 countries.
Contact for Media Inquiries:
SVM PR
baylorgenetics@svmpr.com
(401) 490-9700
