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Variant Resolution Testing Policy

Baylor Genetics offers no-cost targeted testing for up to two relatives as specified below, when required to clarify the clinical significance of variants found in a proband that had Whole Exome Sequencing (WES), Whole Genome Sequencing (WGS), or Next-Generation Sequencing (NGS) Panels (excluding carrier screening or PreSeek™).

No-cost targeted testing in relatives is offered up to 180 days from the original proband report date. Relatives’ test results will be included in an updated report for the proband. No reports will be issued for the tested relatives, unless specifically requested. Qualification criteria can be discussed prior to sending the relative’s sample by calling 1-800-411-4363 or emailing help@baylorgenetics.com.

Requirements:

  • The proband originally tested underwent testing at Baylor Genetics.
  • The family member is a first-degree relative of the proband.
  • The relative’s testing order and specimen are received within 180 days of the original proband report date.
  • Variants that qualify for no-cost testing must be single nucleotide variants (SNVs) or insertion and deletions (indels) and within the nuclear genome.*
  • The affected/unaffected status must be identified on the test requisition form for the first-degree relatives undergoing the no-cost testing.
  • Variants found on sponsored testing programs will not qualify for no-cost testing.
Inheritance
Eligible Variants
Eligible Relatives
Autosomal recessive
Two or more heterozygous variants, including at least one with a VUS classification
Up to two first-degree relatives
Autosomal dominant
VUS that are absent from population databases (gnomAD v4.1.0)
Up to two first-degree relatives
X-linked
VUS that are absent from population databases (gnomAD v4.1.0)
Up to two first-degree male relatives preferred; other relatives may be considered, depending on family structure (contact gc@baylorgenetics.com)

Orders for no-cost variant resolution testing must be placed under test code 1594 (Proband Variant Resolution).

DISCLAIMER
*The criteria above represents the minimum requirements as other restrictions could apply. Copy number variants, mitochondrial variants, short tandem repeats, and other variant types do not qualify for no-cost testing under this policy. Prenatal familial variant testing does not qualify for no-cost testing under this policy. Baylor Genetics may change this policy in its discretion, without notice.