Next-Generation Sequencing to Diagnose Suspected Genetic Disorders

Clinical next-generation sequencing is being used frequently in medical practices in which genetic testing has traditionally taken place —
for example, medical genetics and medical subspecialties such as neurogenetics. Emerging diagnostic applications include rapid-reporting approaches in
intensive care settings (especially neonatal and pediatric)1
and use early in the course of complex disease.2
Large-scale projects in the United States, China, and elsewhere are exploring and developing the role of clinical next-generation sequencing
in precision medicine.3,4 This suggests a future in which genomic data will influence
medical decision making for a diverse and growing group of patients.