Eric Schmitt

MS, CGC, PhD
Genetic Counselor

Eric Schmitt is currently serving as a Senior Genetic Counselor at Baylor Genetics. Prior to joining BG, Eric has performed a wide range of duties including client services, data review, carrier and reproductive risk assessments, and reporting. Currently, he works on variant curation, distillation of clinical summaries, special projects, and providing guidance in biochemical, metabolomic, and mitochondrial testing. 

In addition to his role at BG, Eric is an Assistant Professor at Baylor College of Medicine (BCM) and also teaches at MD Anderson Cancer Center. He also assists the genetic counseling training programs at BCM and the University of Texas. 

Eric has a PhD in molecular biology from Washington University in St. Louis, MO and an MS in genetic counseling from Brandeis University in Waltham, MA. Previously, Eric worked in a pediatric genetics clinic for several years. In addition, he performed research with multiple experimental genetic systems, including flagellar assembly in algae, genetic engineering of soybean, tRNA suppressor genetics in yeast, and mouse cancer modeling. 

While at BG, Eric has published over 30 journal articles regarding medical genetic studies performed in the BG laboratory. He has also presented at several local and national conferences, as well as online mitochondrial genetics courses for the NSGC, TSGC, NCHPEG, and ACMG.   

Eric volunteers for International Medical Exchange and served as a conference organizer and presenter for recurring medical genetics courses that offer CME training in Kazakhstan. In his spare time, Eric enjoys gardening and DIY projects around the house. After becoming empty nesters in the next year, Eric and his wife hope to further explore the U.S. 

Position

Assistant Professor, Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, United States

Genetic Counselor

Baylor Genetics
Houston, TX, United States

Education

MS from Brandeis University
Waltham, MA, United States

PhD from Washington University
St. Louis, MO, United States

BS from Carnegie-Mellon University
Pittsburgh, PA, United States

Certifications

Certified Genetic Counselor
American Board of Genetic Counseling

Publications
Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA

Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A2, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM (2019). Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA. Nat. Med. PMID: 30692697

Clinical and laboratory interpretation of mitochondrial mRNA variants

Lee-Jun C. Wong, Ting Chen, Eric S. Schmitt,  Jing Wang, Sha Tang, Megan Landsverk, Fangyuan Li, Shulin Zhang, Yue Wang, Victor Wei Zhang, William J. Craigen (2020).Clinical and laboratory interpretation of mitochondrial mRNA variants. Hum Mutat  doi: 10.1002/humu.24082. Online ahead of print. PMID: 32652755

Interpretation of mitochondrial tRNA variants

Lee-Jun C. Wong PhD, Ting Chen, MD, Jing Wang, MD, Sha Tang, PhD, Eric S. Schmitt, PhD, Megan Landsverk, PhD, Fangyuan Li, MD, PhD, Yue Wang, PhD, Shulin Zhang, MD, PhD, Victor Wei Zhang, MD, PhD, William J. Craigen, MD, PhD (2020). Interpretation of mitochondrial tRNA variants. Genet Med 22: 917-926 PMID: 31965079

A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 gene

Li J, Dai H, Feng Y, Tang J, Chen S, Tian X, Gorman E, Schmitt ES, Hansen T, Wang J, Plon SE, Zhang VW, Wong LJ.  A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 geneJ Mol Diagn. 2015 Sep;17(5):545-53.  doi: 10.1016/j.jmoldx. 2015.04.001. [with Press Release]  PMID: 26320870

Capture-based high-coverage NGS: a powerful tool to uncover a wide spectrum of mutation types

Wang J, Yu H, Zhang VW, Tian X, Feng YM, Wang G, Gorman E, Wang H, Lutz RE, Schmitt ES, Peacock S, Wong LJ. Capture-based high coverage NGS: a powerful tool to uncover a wide spectrum of mutation typesGenet in Med. 2016 May;18(5):513-21. doi: 10.1038/gim. 2015.121. Epub 2015 Sep 24.  PMID: 26402642

Transition to next generation analysis of the whole mitochondrial genome: a summary of molecular defects

Tang S, Wang J, Zhang VW, Li FY, Landsverk M, Cui H, Truong CK, Wang G, Chen LC, Graham B, Scaglia F, Schmitt ES, Craigen WJ, Wong LJ. Transition to next generation analysis of the whole mitochondrial genome: a summary of molecular defects. Hum. Mutat. 2013 June;34(6):882-93. Pubmed PMID: 23463613

Mitochondrial DNA polymerase gamma mutations: an ever expanding molecular and clinical spectrum

Tang S, Wang J, Lee NC, Milone M, Halberg MC, Schmitt ES, Craigen WJ, Zhang W, Wong LJ (2011). Mitochondrial DNA polymerase gamma mutations: an ever expanding molecular and clinical spectrum. J Med Genet. 48(10):669-81  PMID: 21880868

Sequence homology at the breakpoint and clinical phenotype of mitochondrial DNA deletion syndromes

Sadikovic B, Wang J, El-Hattab A, Landsverk M, Douglas G, Brundage EK, Craigen WJ, Schmitt ES, Wong LJ (2010). Sequence homology at the breakpoint and clinical phenotype of mitochondrial DNA deletion syndromes.  PLoS One 5(12):e15687  PMID: 211879929

Mutations in the MPV17 gene are responsible for rapidly progressive liver failure in infancy

Wong LJ, Brunetti-Pierri N, Zhang Q, Yazigi N, Bove KE, Dahms BB, Puchowicz MA, Gonzalez-Gomez I, Schmitt ES, Truong CK, Hoppel CL, Chou PC, Wang J, Baldwin EE, Adams D, Leslie N, Boles RG, Kerr DS, Craigen WJ.  (2007). Mutations in the MPV17 gene are responsible for rapidly progressive liver failure in infancy.  Hepatology 46(4):1218-27  PMID: 17694548

Eric Schmitt

MS, CGC, PhD
Genetic Counselor

Eric Schmitt is currently serving as a Senior Genetic Counselor at Baylor Genetics. Prior to joining BG, Eric has performed a wide range of duties including client services, data review, carrier and reproductive risk assessments, and reporting. Currently, he works on variant curation, distillation of clinical summaries, special projects, and providing guidance in biochemical, metabolomic, and mitochondrial testing. 

In addition to his role at BG, Eric is an Assistant Professor at Baylor College of Medicine (BCM) and also teaches at MD Anderson Cancer Center. He also assists the genetic counseling training programs at BCM and the University of Texas. 

Eric has a PhD in molecular biology from Washington University in St. Louis, MO and an MS in genetic counseling from Brandeis University in Waltham, MA. Previously, Eric worked in a pediatric genetics clinic for several years. In addition, he performed research with multiple experimental genetic systems, including flagellar assembly in algae, genetic engineering of soybean, tRNA suppressor genetics in yeast, and mouse cancer modeling. 

While at BG, Eric has published over 30 journal articles regarding medical genetic studies performed in the BG laboratory. He has also presented at several local and national conferences, as well as online mitochondrial genetics courses for the NSGC, TSGC, NCHPEG, and ACMG.   

Eric volunteers for International Medical Exchange and served as a conference organizer and presenter for recurring medical genetics courses that offer CME training in Kazakhstan. In his spare time, Eric enjoys gardening and DIY projects around the house. After becoming empty nesters in the next year, Eric and his wife hope to further explore the U.S. 

Position

Assistant Professor, Molecular and Human Genetics
Baylor College of Medicine
Houston, TX, United States

Genetic Counselor

Baylor Genetics
Houston, TX, United States

Education

MS from Brandeis University
Waltham, MA, United States

PhD from Washington University
St. Louis, MO, United States

BS from Carnegie-Mellon University
Pittsburgh, PA, United States

Certifications

Certified Genetic Counselor
American Board of Genetic Counseling

Publications
Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA

Zhang J, Li J, Saucier JB, Feng Y, Jiang Y, Sinson J, McCombs AK, Schmitt ES, Peacock S, Chen S, Dai H, Ge X, Wang G, Shaw CA, Mei H, Breman A, Xia F, Yang Y, Purgason A2, Pourpak A, Chen Z, Wang X, Wang Y, Kulkarni S, Choy KW, Wapner RJ, Van den Veyver IB, Beaudet A, Parmar S, Wong LJ, Eng CM (2019). Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA. Nat. Med. PMID: 30692697

Clinical and laboratory interpretation of mitochondrial mRNA variants

Lee-Jun C. Wong, Ting Chen, Eric S. Schmitt,  Jing Wang, Sha Tang, Megan Landsverk, Fangyuan Li, Shulin Zhang, Yue Wang, Victor Wei Zhang, William J. Craigen (2020).Clinical and laboratory interpretation of mitochondrial mRNA variants. Hum Mutat  doi: 10.1002/humu.24082. Online ahead of print. PMID: 32652755

Interpretation of mitochondrial tRNA variants

Lee-Jun C. Wong PhD, Ting Chen, MD, Jing Wang, MD, Sha Tang, PhD, Eric S. Schmitt, PhD, Megan Landsverk, PhD, Fangyuan Li, MD, PhD, Yue Wang, PhD, Shulin Zhang, MD, PhD, Victor Wei Zhang, MD, PhD, William J. Craigen, MD, PhD (2020). Interpretation of mitochondrial tRNA variants. Genet Med 22: 917-926 PMID: 31965079

A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 gene

Li J, Dai H, Feng Y, Tang J, Chen S, Tian X, Gorman E, Schmitt ES, Hansen T, Wang J, Plon SE, Zhang VW, Wong LJ.  A comprehensive strategy for accurate mutation detection of the highly homologous PMS2 geneJ Mol Diagn. 2015 Sep;17(5):545-53.  doi: 10.1016/j.jmoldx. 2015.04.001. [with Press Release]  PMID: 26320870

Capture-based high-coverage NGS: a powerful tool to uncover a wide spectrum of mutation types

Wang J, Yu H, Zhang VW, Tian X, Feng YM, Wang G, Gorman E, Wang H, Lutz RE, Schmitt ES, Peacock S, Wong LJ. Capture-based high coverage NGS: a powerful tool to uncover a wide spectrum of mutation typesGenet in Med. 2016 May;18(5):513-21. doi: 10.1038/gim. 2015.121. Epub 2015 Sep 24.  PMID: 26402642

Transition to next generation analysis of the whole mitochondrial genome: a summary of molecular defects

Tang S, Wang J, Zhang VW, Li FY, Landsverk M, Cui H, Truong CK, Wang G, Chen LC, Graham B, Scaglia F, Schmitt ES, Craigen WJ, Wong LJ. Transition to next generation analysis of the whole mitochondrial genome: a summary of molecular defects. Hum. Mutat. 2013 June;34(6):882-93. Pubmed PMID: 23463613

Mitochondrial DNA polymerase gamma mutations: an ever expanding molecular and clinical spectrum

Tang S, Wang J, Lee NC, Milone M, Halberg MC, Schmitt ES, Craigen WJ, Zhang W, Wong LJ (2011). Mitochondrial DNA polymerase gamma mutations: an ever expanding molecular and clinical spectrum. J Med Genet. 48(10):669-81  PMID: 21880868

Sequence homology at the breakpoint and clinical phenotype of mitochondrial DNA deletion syndromes

Sadikovic B, Wang J, El-Hattab A, Landsverk M, Douglas G, Brundage EK, Craigen WJ, Schmitt ES, Wong LJ (2010). Sequence homology at the breakpoint and clinical phenotype of mitochondrial DNA deletion syndromes.  PLoS One 5(12):e15687  PMID: 211879929

Mutations in the MPV17 gene are responsible for rapidly progressive liver failure in infancy

Wong LJ, Brunetti-Pierri N, Zhang Q, Yazigi N, Bove KE, Dahms BB, Puchowicz MA, Gonzalez-Gomez I, Schmitt ES, Truong CK, Hoppel CL, Chou PC, Wang J, Baldwin EE, Adams D, Leslie N, Boles RG, Kerr DS, Craigen WJ.  (2007). Mutations in the MPV17 gene are responsible for rapidly progressive liver failure in infancy.  Hepatology 46(4):1218-27  PMID: 17694548

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